COSAFA side Madagascar could seal a first ever appearance at the Africans Nations Cup finals if they beat Equatorial Guinea in their home qualifier on Tuesday.
Victory would mean the islanders could not finish outside of the top two in their Group A, sealing their historic place in the expanded Nations Cup finals field having first entered the qualifiers in 1972.
They would also be the first COSAFA nation advance to the finals next June-July, though there are others that stand on the brink.
Malawi must beat Cameroon at home to stay in contention in Group B, while South Africa can move to within a point of qualification of they get another win against fellow COSAFA side Seychelles.
Bafana Bafana secured a record 6-0 victory over the islanders in Soweto on Saturday and will look for more of the same in Victoria.
Zimbabwe can also move to the brink of qualification if they get a home win over DR Congo, having stunned the same opposition in Kinshasa at the weekend.
They will be without suspended forward Knowledge Musona after he was red-carded in the last game.
Angola claimed a handsome 4-0 win over Mauritania in their home qualifier at the weekend, but now face a difficult trip to West Africa in what is a tight Group I.
They have six points, the same number as Burkina Faso and Mauritania, while Botswana are yet to break their duck.
Swaziland stand on the brink of elimination in Group J unless they can get a victory at home to Egypt, who will be without talisman Mo Salah through injury.
Namibia cane take a big step towards qualification with a home win against fellow COSAFA side Mozambique in Group K, with both teams on four points. As are Zambia, who were surprise 2-1 losers in Guinea-Bissau on Sunday. Chipolopolo have played a game more.
Finally, Lesotho need victory in Group L to keep their hopes alive as they host table-topping Uganda.